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ESTIMASI DOSIS 99mTc-PERTEHNETAT DARI GENERATOR 99Mo / 99mTc NON-FISI PADA ANAK-ANAK USIA 1-15 TAHUN UNTUK PROSEDUR DIAGNOSTIK

Lafira Lafira(1), Nur Rahmah Hidayati(2), Syarifatul Ulya(3), Arni Aries(4), Marlina Marlina(5), Ramlan Ramlan(6),


(1) Sriwijaya University
(2) Pusat Riset Teknologi Keselamatan, Metrologi, dan Mutu Nuklir, Organisasi Riset Tenaga Nuklir, Badan Riset dan Inovasi Nasional (BRIN)
(3) Pusat Riset Teknologi Keselamatan, Metrologi, dan Mutu Nuklir, Organisasi Riset Tenaga Nuklir, Badan Riset dan Inovasi Nasional (BRIN)
(4) Pusat Riset Teknologi Radioisotop, Radiofarmaka dan Biodosimetri, Organisasi Riset Tenaga Nuklir, Badan Riset dan Inovasi Nasional (BRIN)
(5) Pusat Riset Teknologi Radioisotop, Radiofarmaka dan Biodosimetri, Organisasi Riset Tenaga Nuklir, Badan Riset dan Inovasi Nasional (BRIN)
(6) Jurusan Fisika, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Sriwijaya
Corresponding Author

Abstract


99mTc-pertehnetat berguna untuk pengobatan yang disertai dengan adanya info pemberian dosis ke tubuh manusia. Penelitian ini bertujuan untuk mengetahui estimasi dosis radiofarmaka 99mTc Pertehnetat pada anak-anak usia 1-15 tahun. Metode penelitian ini dilakukan dengan berbasis uji biodistribusi mencit dengan interval waktu 0,5, 1, 3, 5, 24 jam pasca injeksi radiofarmaka. Dari data hasil uji biodistribusi diperoleh %ID/gram organ mencit, dikonversikan ke %ID/gram organ manusia. Setelah itu, hasil perhitungan diinput ke software OLINDA/EXM dengan mengamati perbedaan dosis efektif untuk anak-anak usia 1-15 tahun. Berdasarkan nilai %ID/gram organ manusia masing-masing aktivitas uptake pada interval waktu pasca injeksi dari organ tertinggi dihasilkan yaitu, otot, hati, paru-paru, dan lambung. Hasil perbandingan dosis efektif OLINDA/EXM  menggunakan t hewan dan t manusia dapat diketahui hasil yang diperoleh menghasilkan nilai dosis efektif yang lebih kecil dibandingkan setelah dikonversi ke t manusia. Rata-rata dosis serap dari organ tertinggi pada OLINDA/EXM berada di tiroid, lambung, paru-paru dan. Hasil dosis efektif yang diperoleh untuk usia 1 tahun  1.11 x 10-2, 5 tahun 6.01 x 10-3 , 10 tahun 3.96 x 10-3 dan 15 tahun 2.50 x 10-3 . Oleh sebab itu, besar dosis efektif yang dihasilkan semakin besar terhadap umur pasien yang lebih muda.

Keywords


99mTc-Pertehnetat; Uji Biodistribusi; Dosimetri Internal

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DOI: 10.55981/gnd.2023.6853

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