STUDI IN VITRO BIOBIODEGRADASI MICROSPHERE POLILAKTAT

Sudaryanto Sudaryanto, Wahyudianingsih Wahyudianingsih, Ari Handayani, Muhammad Nazri Robani

DOI: http://dx.doi.org/10.17146/jsmi.2006.7.2.4998

Abstract


STUDI IN VITRO BIOBIODEGRADASI MICROSPHERE POLILAKTAT. Biodegradasi polimer microsphere berbasis polilaktat (PLA) telah dilakukan secara in vitro pada lingkungan yang mendekati kondisi dalamtubuhmanusia (pH 7,4 dan suhu 37°C). Proses degradasi microsphere PLA diamati berdasarkan perubahan morfologi permukaan microsphere, entalpi pelelehan, dan berat molekul, yangmasing-masing diuji menggunakan alat Scanning Electron Microscope (SEM), Differential Scanning Calorimetry (DSC), dan Gel Permeation Chromatography (GPC). Proses biodegradasi microsphere PLA tampak nyata setelah inkubasi selama 4 minggu. Tetapi, secara keseluruhan proses biodegradasi PLA berjalan lambat, hal itu dikarenakan munculnya sejumlah microsphere baru dari microsphere besar yang telah terbiodegradasi.

Keywords


Microsphere, polilaktat, biodegradasi, invitro

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