KARAKTERISTIK PEMISAHAN RADIOLUTESIUM-177/177mLu DAN RADIOITERBIUM-169/175Yb PADA KOLOM RESIN LN-EICHROM

Abstract

ABSTRAK

KARAKTERISTIK PEMISAHAN RADIOLUTESIUM- ^177/177mLu DAN RADIOITERBIUM-^169/175Yb PADA KOLOM RESIN LN-EICHROM. Radiolutesium-¹⁷⁷Lu keradioaktifan jenis tinggi merupakan salah satu radiolantanida yang banyak digunakan untuk menangani berbagai kasus kanker, namun di Indonesia penggunaan radiofarmaka bertanda ¹⁷⁷Lu belum dapat dijanjikan karena teknik produksi radioisotop primernya belum dikuasai. Prospek produksi ¹⁷⁷Lu melalui reaksi inti ¹⁷⁶Yb (n,g) ¹⁷⁷Yb^* à ¹⁷⁷Lu^* + β^– dipelajari melalui metode pemisahan matrik ^177/177mLu-^169/175Yb/¹⁷⁶Yb dalam sistem kromatografi kolom resin LN-Eichrom. Profil fraksinasi dan karakteristik pemisahan dipelajari dengan pemeriksaan keradioaktifan dan analisis spektro-metri-g terhadap hasil elusi larutan sasaran pasca iradiasi. Bahan sasaran digunakan ¹⁷⁶Yb₂O₃ alam dan ¹⁷⁶Lu₂O₃ diperkaya. Hasil penelitian menunjukkan bahwa radiolutesium-^177/177mLu dapat dipisahkan dari matrik radioiterbium-^169/175Yb/^natYb melalui sistem kromatografi kolom dengan fase diam resin LN-Eichrom dan fase gerak larutan HNO₃, dengan konsentrasi antara 1,5 – 4 M untuk mendapatkan pemisahan yang efektif, selektif dan kuantitatif. Reaksi inti ¹⁷⁶Yb(n,g) ¹⁷⁷Yb^* à ¹⁷⁷Lu + β^– merupakan model reaksi inti yang perlu dipertimbangkan walau-pun harus melibatkan tahapan pemisahan produk ¹⁷⁷Lu dari matrik sasaran Yb pasca iradiasi. Prosedur pemisahan yang dilakukan masih perlu diperbaiki melalui pemilihan jenis dan konsentrasi fase gerak pengelusi yang lebih tepat.

ABSTRACT

SEPARATION CHARACTERISTIC OF RADIOLUTETIUM-^177/177mLu AND RADIOY-TTERBIUM-^169/175Yb ON LN-EICHROM RESIN COLUMN. High specific activity radiolutetium-¹⁷⁷Lu is one of radiolanthanides that is widely used to handle variety of cancer cases, but in Indonesia the use of ¹⁷⁷Lu-labeled-radiopharmaceutical can not be promised yet as the primary radioisotope production techniques have not been mastered.  The  prospect of ¹⁷⁷Lu production based on the nuclear reaction of ¹⁷⁶Yb (n,g) ¹⁷⁷Yb * ® ¹⁷⁷Lu * + β^– in the BATAN’s G.A. Siwabessy reactor was learned through the separation characteristics of ^177/177mLu-^169/175Yb /¹⁷⁶Yb process matrices in the LN-Eichrom resin column chromatography. The separation and fractionation profiles were characterized by radioactivity measurement as well as g-spectrometric analysis of the eluting post-irradiated target solution. The target materials used were natural ¹⁷⁶Yb₂O₃ and enriched ¹⁷⁶Lu₂O₃. The results showed that radiolutetium-^177/177mLu can be separated from the radioiterbium-^169/175Yb/^natYb matrix by column chromatography system with a stationary phase of LN-Eichrom resin using HNO₃ solution as the mobile phase, but the concentration of HNO₃ used is a critical variable, between 1.5 - 4 M, to obtain an effective separation selectively and quantitatively. The nuclear reaction of ¹⁷⁶Yb (n,g) ¹⁷⁷Yb* ® ¹⁷⁷Lu + β^– using natural Yb₂O₃ is considered to be better, although it must involve ¹⁷⁷Lu product separation stage from the post-irradiated natural Yb target matrix. The presented separation procedure still needs to be improved through the selection of the type and the concentration of the mobile phase used to gain more appropriate elution solvent.