PREPARATION OF HYDROXYAPATITE POWDERS FOR MEDICALAPPLICATIONS VIA SOL-GEL TECHNIQUE

Iis Sopyan

DOI: http://dx.doi.org/10.17146/jsmi.2003.4.2.4883

Abstract


PREPARATION OF HYDROXYAPATITE POWDERS FOR MEDICALAPPLICATIONS VIA SOL-GEL TECHNIQUE. Hydroxyapatite (HA) powders have been prepared via sol-gel procedure using calcium nitrate tetrahydrate and di-ammonium hydrogen phosphate as the precursors for calcium and phosphorus, respectively. An ammoniacal solution of the monomers was heated at 100°C for about 3 –4 h until a white gel of hydroxyapatite mixture were obtained. The obtained gel was then dried at 340°C for 7 h and subsequently subjected to an 820°C calcination for 2 h. The yield of the powder mixture ranged between 50 to 53 g. XRD measurement shown that the powder contained hydroxyapatite crystal with b-TCP ( 15-20%) and calcium oxide (4-6%) as secondary phases. Further treatment was conducted to gain hydroxyapatite powder of higher purity, thus the correct Ca/P ratio, by adding an appropriate amount of di-ammonium hydrogen phosphate and heated while stirring at 90°C for 4 h. Good purity (almost 100%) of the obtained hydroxyapatite was confirmed by XRD analysis.This result proved that our HA powder meets the medical prerequisite: a HA purity of above 95%. Morphological evaluation by SEM measurement shows that the particles of the HA agglomerate are globular in shape with an average size of 1-2 mm in diameter. Meanwhile, the primary particles have a diameter of 70-150 nm in average. Surface area of the powder is 7 m2/g and the mean particle size as measured using X ray sedimentation method is ca. 1 mm. The measurements are not in good agreement with the morphological investigation. We consider, accordingly, that the particles presumably have high surface potentials, thus forming very tightly bonded agglomerates

Keywords


Hydroxyapatite Powder, Sol-Gel, Medical Application, Preparation, Characterization

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